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Intramyocellular lipid quantification: repeatability with 1H MR spectroscopy.

Martin Torriani1, Bijoy J Thomas, Elkan F Halpern

  • 1Division of Musculoskeletal Imaging and Institute for Technology Assessment, Massachusetts General Hospital and Harvard Medical School, 15 Parkman St, WACC 515, Boston, MA 02114, USA. mtorriani@hms.harvard.edu

Radiology
|July 26, 2005
PubMed
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Hydrogen 1 magnetic resonance (MR) spectroscopy offers repeatable quantification of intramyocellular lipids (IMCL) in the tibialis anterior muscle. Nonbiologic factors contribute to variability, but changes over 15% are detectable for future muscle metabolism studies.

Area of Science:

  • Biomedical Engineering
  • Musculoskeletal Imaging
  • Metabolic Research

Background:

  • Intramyocellular lipids (IMCL) are crucial indicators of muscle metabolism.
  • Accurate and repeatable quantification of IMCL is essential for longitudinal studies.
  • 1.5-T hydrogen 1 (1H) MR spectroscopy is a promising technique for IMCL assessment.

Purpose of the Study:

  • To prospectively evaluate the repeatability and variability of tibialis anterior IMCL quantification using 1.5-T 1H MR spectroscopy.
  • To assess the impact of nonbiologic factors on IMCL measurement consistency.
  • To determine the sample size needed to detect significant changes in IMCL over time.

Main Methods:

  • 27 healthy subjects underwent 1H MR spectroscopy of the tibialis anterior muscle.

Related Experiment Videos

  • Measurements were repeated within-day and across a mean interval of 12 days.
  • Spectra were analyzed using jMRUI and LCModel, with lipid peaks scaled to water and creatine peaks.

    • Main Results:

    • The IMCL methylene protons peak scaled to the water peak (IMCL(W)) showed the lowest coefficients of variation (CVs): 13.4% intraday and 14.4% intervisit.
    • Nonbiologic factors, including equipment and repositioning, accounted for 50% of total variability.
    • A sample size of 20 subjects can detect changes in IMCL(W) greater than 15%.

    Conclusions:

    • 1H MR spectroscopy provides feasible and repeatable quantification of IMCL concentrations.
    • The technique is suitable for longitudinal studies investigating muscle metabolism.
    • Understanding variability sources is key for interpreting IMCL changes in research.