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Sinus node dysfunction concomitant with Brugada syndrome.

Masataka Sumiyoshi¹, Yuji Nakazato, Takashi Tokano

¹Department of Cardiology, Juntendo University Shizuoka Hospital, Shizuoka, Japan. sumi@med.juntendo.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society

|July 26, 2005

Summary

Sinus node dysfunction (SND) frequently co-occurs with Brugada syndrome (BS), suggesting a potential genetic link. This finding is crucial for understanding and managing patients with these related cardiac conditions.

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Area of Science:

Cardiology
Genetics
Electrophysiology

Background:

Brugada syndrome (BS) and sinus node dysfunction (SND) are cardiac conditions with a suspected genetic correlation.
Clinical and electrophysiologic features of concomitant BS and SND are not well-defined.

Purpose of the Study:

To investigate the clinical and electrophysiologic characteristics of patients with coexisting Brugada syndrome and sinus node dysfunction.

Main Methods:

Case series analysis of 5 patients with symptomatic Brugada syndrome.
Review of clinical history, electrophysiologic study findings, and treatment outcomes.
Assessment for sinus pauses, sinus node recovery time, and arrhythmias like atrial fibrillation/flutter.

Main Results:

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Three of five patients with Brugada syndrome exhibited significant sinus pauses (>3 seconds).
Electrophysiologic studies revealed prolonged sinus node recovery time in two patients.
Two patients with SND and BS required pacemaker implantation, and three received implantable cardioverter-defibrillators.

Conclusions:

Sinus node dysfunction is a common co-occurring condition in Brugada syndrome.
A possible genetic connection between Brugada syndrome and sinus node dysfunction is suggested.