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[Cerebral phlebitis and Crohn disease]
1Service de Neurologie, CHU Timone, Marseille.
Revue Neurologique
|January 1, 1992
Summary
Crohn's disease patients may experience superior sagittal sinus thrombosis, even during remission. Hematological abnormalities like thrombocytosis and increased fibrinogen may contribute to this risk.
Area of Science:
- Neurology
- Gastroenterology
- Hematology
Background:
- Inflammatory bowel disease (IBD), such as Crohn's disease, is associated with an increased risk of thrombotic events.
- Cerebral venous thrombosis (CVT) is a rare but serious complication that can occur in patients with IBD.
Observation:
- A 17-year-old male with a history of Crohn's disease presented with superior sagittal sinus thrombosis during clinical remission.
- Neurological symptoms rapidly improved with treatment.
Findings:
- Hematological investigations revealed thrombocytosis, spontaneous platelet aggregation, elevated fibrinogen levels, increased plasma viscosity, and enhanced red blood cell aggregability.
- Mild hypofibrinolysis and the presence of antiphospholipid antibodies were also observed.
- A review of nine documented cases of CVT associated with IBD is presented.
Implications:
- Thrombocytosis and other hematological alterations may play a prothrombotic role in IBD patients.
- This case highlights the importance of considering thrombotic complications in IBD patients, even in apparent remission.
- Further research is warranted to elucidate the mechanisms linking IBD and CVT.