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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Quantitative MRI: hidden age-related changes in brain tissue.

Matilde Inglese¹, Yulin Ge

¹Department of Radiology, New York University School of Medicine, New York, NY 10016, USA. matilde.inglese@med.nyu.edu

Topics in Magnetic Resonance Imaging : TMRI

|July 26, 2005

Summary

Advanced magnetic resonance imaging (MRI) techniques reveal subtle aging brain changes. These methods track microstructural and metabolic shifts in vivo, aiding understanding of cognitive decline.

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Area of Science:

Neuroimaging
Gerontology
Biomedical Engineering

Background:

Conventional MRI offers limited insight into age-related brain microstructural alterations.
Post-mortem studies reveal significant tissue changes with aging.
In vivo imaging is crucial for understanding normal aging and neurodegeneration.

Purpose of the Study:

To review advanced quantitative magnetic resonance imaging (MRI) techniques.
To highlight MRI methods sensitive to occult age-related brain changes.
To emphasize the importance of in vivo characterization of aging brain tissue.

Main Methods:

Magnetization transfer imaging
Diffusion tensor imaging
Proton magnetic resonance spectroscopy

Main Results:

Quantitative MRI techniques detect microstructural and metabolic changes in aging gray and white matter.
These advanced methods provide in vivo insights into normally aging brains.
The techniques are sensitive to subtle, previously undetectable age-related alterations.

Conclusions:

Innovative quantitative MRI techniques are vital for studying subtle aging brain changes.
In vivo characterization of molecular and cellular changes is key to understanding cognitive decline.
These methods aid in interpreting changes observed in neurodegenerative diseases.