Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Mixed pre- and postsynaptic neuromuscular block].

P Rondepierre1, A Furby, O Godefroy

  • 1Service de Neurologie B, Centre hospitalo-universitaire de Lille.

Revue Neurologique
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

L-DOPA-induced dyskinesias, motor fluctuations and health-related quality of life: the COPARK survey.

European journal of neurology·2017
Same author

Heterozygous CLCN1 mutations can modulate phenotype in sodium channel myotonia.

Neuromuscular disorders : NMD·2014
Same author

[Continuous subcutaneous infusion of apomorphine in Parkinson's disease: retrospective analysis of a series of 81 patients].

Revue neurologique·2014
Same author

[Impulse control disorders in Parkinson's disease: A cohort of 35 patients].

Revue neurologique·2011
Same author

Long-term improvement under deferiprone in a case of neurodegeneration with brain iron accumulation.

Parkinsonism & related disorders·2011
Same author

Prognostic value of EEG in very premature newborns.

Archives of disease in childhood. Fetal and neonatal edition·2011
Same journal

Macrophage inclusions in patients undergoing antisense oligonucleotide therapy for ALS or SMA: A retrospective and transversal study.

Revue neurologique·2026
Same journal

Geographic disparities in MRI features of ischemic stroke and small vessel disease: A comparative study between French Guiana and mainland France. Findings from the BECATOUR multicenter registry.

Revue neurologique·2026
Same journal

Continuous subcutaneous perfusion of apomorphine in Parkinson's disease: Towards monotherapy?

Revue neurologique·2026
Same journal

Neuro-Whipple presenting as autoimmune encephalitis.

Revue neurologique·2026
Same journal

Multimodal assessment of minimally conscious state and cognitive motor dissociation in neurocritical care: A critical review.

Revue neurologique·2026
Same journal

Development of a new episodic memory assessment tool (NEM): Preliminary data and clinical perspectives.

Revue neurologique·2026
See all related articles

This study details a rare neuromuscular block overlap between Myasthenia Gravis and Eaton-Lambert syndrome. Diagnosis requires specific clinical and electrophysiological criteria, with treatment involving guanidine and anticholinesterase drugs.

Area of Science:

  • Neurology
  • Clinical Electrophysiology
  • Immunology

Background:

  • Myasthenia Gravis (MG) and Lambert-Eaton Myasthenic Syndrome (LEMS) are distinct autoimmune disorders affecting neuromuscular transmission.
  • Overlap syndromes are rare, presenting diagnostic challenges due to overlapping clinical and electrophysiological features.
  • Understanding these overlaps is crucial for accurate diagnosis and effective treatment.

Observation:

  • A 64-year-old male presented with exercise-induced ophthalmoplegia, gait disturbance, limb weakness, and areflexia.
  • Clinical findings included ptosis and left eye abduction palsy.
  • High anti-acetylcholine receptor antibody levels were detected, alongside specific electrophysiological abnormalities.

Findings:

  • Electrophysiological findings included a 3 Hz decrement, 30 Hz increment, and reduced initial motor potential amplitude.

Related Experiment Videos

  • The patient showed improvement with guanidine and anticholinesterase therapy.
  • Four diagnostic criteria for this neuromuscular block overlap were proposed based on this case and prior literature.

    • Implications:

    • The proposed criteria aid in diagnosing rare neuromuscular block overlaps.
    • This research highlights the importance of comprehensive electrophysiological testing and antibody profiling.
    • Effective management strategies involve a combination of pharmacotherapies targeting neuromuscular transmission.