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Related Experiment Videos

Circulating serotonin in vertebrates.

E Maurer-Spurej1

  • 1Department of Pathology, University of British Columbia, Vancouver, Canada. emaurer@interchange.ubc.ca

Cellular and Molecular Life Sciences : CMLS
|July 26, 2005
PubMed
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This study found serotonin in bird and reptile blood cells, suggesting a link to body temperature regulation in warm-blooded animals. This discovery offers new insights into serotonin

Area of Science:

  • Comparative physiology
  • Evolutionary biology
  • Biochemistry

Background:

  • The function of circulating serotonin remains largely unknown.
  • Its presence in non-mammalian species' blood is not established.

Purpose of the Study:

  • To investigate the presence of serotonin in the blood of non-mammalian vertebrates.
  • To explore the potential link between serotonin, blood flow, and thermoregulation.

Main Methods:

  • Analysis of thrombocytes (blood cells) from various bird, reptile, amphibian, and fish species.
  • Detection of serotonin using appropriate biochemical assays.
  • Comparative analysis across different species and phylogenetic groups.

Main Results:

Related Experiment Videos

  • Serotonin was detected in thrombocytes of birds, leatherback sea turtles, green sea turtles, and American alligators.
  • Thrombocytes from freshwater turtles, American bullfrogs, Yellowfin tuna, and Chinook salmon lacked serotonin.
  • Evidence suggests a correlation between serotonin presence in circulating blood and endothermy (warm-bloodedness).

    • Conclusions:

    • This study provides the first evidence of serotonin in avian and reptilian thrombocytes.
    • The findings support a role for circulating serotonin in thermoregulation, particularly in endothermic species.
    • An evolutionary divergence in serotonin presence among reptiles may be linked to the development of endothermy.