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06:29
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Pathophysiology of hemolytic transfusion reactions
1Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0054, USA. rddvnprt@umich.edu
Seminars in Hematology
|July 26, 2005
Summary
Hemolytic transfusion reactions (HTR) involve immune red blood cell (RBC) incompatibility. Targeting complement or cytokines may treat severe HTRs, drawing parallels to systemic inflammatory response syndrome (SIRS).
Area of Science:
- Immunology
- Transfusion Medicine
- Pathophysiology
Background:
- Hemolytic transfusion reactions (HTR) are triggered by immune red blood cell (RBC) incompatibility.
- HTR share characteristics with systemic inflammatory response syndrome (SIRS).
Purpose of the Study:
- To explore the pathophysiologic mechanisms of HTR.
- To identify potential therapeutic targets for severe HTR.
Main Methods:
- Review of clinical and experimental observations of HTR.
- Analysis of the phases of immune response in HTR.
Main Results:
- HTR involve humoral immunity, phagocyte activation, cytokine production, and cellular responses.
- HTR share features with SIRS, suggesting overlapping inflammatory pathways.
Conclusions:
- Understanding HTR pathophysiology reveals potential therapeutic strategies.
- Biological agents targeting complement or cytokines may treat severe HTRs.
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