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Plasma Proteome Database as a resource for proteomics research.

Babylakshmi Muthusamy1, G Hanumanthu, Shubha Suresh

  • 1Institute of Bioinformatics, Bangalore, India.

Proteomics
|July 26, 2005
PubMed
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This summary is machine-generated.

This study comprehensively annotates human plasma proteins, revealing over half encode multiple isoforms. This detailed functional annotation aids in understanding disease diagnosis through plasma biomarkers.

Area of Science:

  • Proteomics
  • Human Physiology
  • Biochemistry

Background:

  • Plasma is a crucial body fluid for disease diagnosis.
  • Previous studies have identified numerous plasma proteins.
  • The Human Proteome Organization (HUPO) initiated the Plasma Proteome Project.

Purpose of the Study:

  • To provide a detailed functional annotation of all identified human plasma proteins.
  • To create a comprehensive database of the plasma proteome.
  • To analyze protein isoforms, single nucleotide polymorphisms, and their functional implications.

Main Methods:

  • Annotation of gene products based on literature and HUPO's Plasma Proteome Project data.
  • Identification of multiple peptides from proteins.
  • Mapping of single nucleotide polymorphisms (SNPs) onto protein sequences.

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Main Results:

  • Functional annotation of 3778 distinct genes encoding plasma proteins.
  • Discovery that 51% of these genes encode multiple protein isoforms.
  • Identification of isoform-specific subcellular localization and tissue expression patterns.

Conclusions:

  • The plasma proteome is complex, with significant isoform diversity.
  • Detailed annotation facilitates understanding of protein function and variation.
  • The developed database serves as a valuable resource for plasma proteome research and disease biomarker discovery.