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Evaluation of glucose metabolism profile in coronary disease. Prospective study in hospitalized patients

Rui Candeias1, Sanjiva Cacodecar, Veloso Gomes

  • 1Serviço de Cardiologia do Hospital Distrital de Faro, Faro, Portugal.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|July 27, 2005
PubMed

Insights

A high prevalence of diabetes and prediabetic conditions exists in coronary disease patients. Many patients with coronary disease have undiagnosed glucose metabolism disorders, highlighting the need for systematic screening.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Growing prevalence of diabetes mellitus, predicted to affect 300 million by 2025.
  • Undiagnosed glucose metabolism disorders are significant risk factors for coronary disease.
  • Prediabetic conditions (impaired glucose tolerance, impaired fasting glucose) worsen coronary disease prognosis.

Purpose of the Study:

  • Evaluate the prevalence of glucose metabolism disorders in hospitalized coronary disease patients.
  • Identify undiagnosed diabetes or prediabetic conditions in this cohort.

Main Methods:

  • Prospective study of 44 consecutive coronary disease patients.
  • Measured fasting plasma glucose and performed oral glucose tolerance tests (75g glucose).
  • Classified glucometabolic state using World Health Organization (1999) criteria.

Main Results:

  • Diabetes prevalence was 43.2% (19 patients), with 15.9% (7 patients) previously undiagnosed.
  • Impaired glucose tolerance identified in 25% (11 patients).
  • Impaired fasting glucose identified in 2.3% (1 patient) and combined in 2.3% (1 patient).

Conclusions:

  • Glucose metabolism disorders are highly prevalent in patients with coronary disease.
  • A significant number of coronary patients have asymptomatic, undiagnosed diabetes or prediabetes.
  • Systematic oral glucose tolerance testing during hospitalization can facilitate early detection and management.
Abstract

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