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Related Experiment Videos

Pratical aspects of testosterone substitution.

C Wang1, R S Swerdloff

  • 1Division of Endocrinology, Department of Medicine Harbor-UCLA Medical Center and Los Angeles Biomedical Research Center, Torrance, USA. wang@labiomed.org

Journal of Endocrinological Investigation
|July 27, 2005
PubMed
Summary

Testosterone (T) therapy for older men with hypogonadism requires careful consideration of benefits versus risks. Treatment should focus on symptom improvement and close monitoring for adverse effects.

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Area of Science:

  • Endocrinology
  • Geriatrics
  • Men's Health

Background:

  • Hypogonadism in older men is characterized by symptoms and low serum testosterone (T) levels.
  • Testosterone replacement therapy (TRT) is a potential treatment option for these individuals.

Purpose of the Study:

  • To provide guidance on the careful consideration of testosterone (T) substitution in hypogonadal older men.
  • To highlight the importance of discussing benefits versus risks with patients.

Main Methods:

  • Review of current understanding regarding testosterone treatment in older men.
  • Emphasis on careful patient assessment and symptom evaluation.
  • Monitoring for adverse events associated with androgen therapy.

Main Results:

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  • Symptoms of hypogonadism and low serum T levels are generally considered indications for treatment.
  • Short-acting T preparations may be preferred for aging men.
  • Maintaining serum T levels within the mid-adult range is a treatment goal.

Conclusions:

  • Until more efficacy and risk data are available, TRT in older men warrants cautious consideration.
  • Close monitoring for prostate disease, erythrocytosis, and other adverse events is critical.
  • The primary goal of treatment is the careful assessment of symptom improvement.