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Updated: Aug 16, 2026

Monochrome Multiplex Quantitative PCR Telomere Length Measurement
Published on: March 22, 2024
Clonal granulocytes in polycythaemia vera and essential thrombocythaemia have shortened telomeres
Anna Maria Ferraris1, Natalija Pujic, Rosa Mangerini
1Ematologia Oncologica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. annamaria.ferraris@istge.it
Abstract:
Summary The purpose of this study was to evaluate telomere length in peripheral blood granulocytes and mononuclear cells collected from 22 women with polycythaemia vera (PV) and essential thrombocythaemia (ET). PV and ET are chronic myeloproliferative diseases whose heterogeneity of stem cell origin and clonal development has been established through analysis of X-chromosome inactivation patterns. The results from clonality assay and determination of telomere length show that only clonal granulocytes have shortened telomeres.
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