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Efficacy of tolterodine as a first-line treatment for non-neurogenic voiding dysfunction in children

Semih Ayan1, Kemal Kaya, Kahraman Topsakal

  • 1Department of Urology, Medical Faculty, Cumhuriyet University, Sivas, Turkey. sayan@cumhuriyet.edu.tr

BJU International
|July 27, 2005
PubMed

Insights

First-line treatment with tolterodine and behavioral modification significantly improved symptoms in children with dysfunctional voiding. This approach offers a safe and effective alternative to invasive evaluations for pediatric voiding dysfunction.

Area of Science:

  • Pediatric Urology
  • Pharmacology
  • Behavioral Therapy

Background:

  • Non-neurogenic voiding dysfunction is common in children.
  • Current treatment often involves invasive investigations.
  • A need exists for effective first-line, non-invasive therapies.

Purpose of the Study:

  • To evaluate tolterodine combined with behavioral modification as a first-line treatment for pediatric voiding dysfunction.
  • To assess the efficacy of this combined approach before resorting to invasive evaluations.
  • To determine if this treatment is suitable for children without neurological or anatomical abnormalities.

Main Methods:

  • A study involving 44 children (30 girls, 14 boys) with voiding dysfunction.
  • Noninvasive evaluation including history, urinalysis, and imaging.
  • Treatment with tolterodine (1 mg twice daily) and behavioral modifications (timed voiding, pelvic floor relaxation).
  • Dysfunctional Voiding Symptom Score (DVSS) assessed at baseline and 3 months.

Main Results:

  • The mean DVSS significantly decreased from 14.0 to 6.68 after treatment (P < 0.001).
  • Both girls and boys showed significant improvements in DVSS scores.
  • The treatment was well-tolerated in the pediatric population.

Conclusions:

  • Tolterodine and behavioral modification are effective first-line treatments for pediatric voiding dysfunction.
  • This combined therapy can be recommended before invasive investigations.
  • The DVSS is a reliable tool for monitoring treatment outcomes in children with voiding dysfunction.
Abstract

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