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Related Experiment Videos

Inflammatory bowel disease and preterm delivery.

Gabby Elbaz1, Alex Fich, Amalia Levy

  • 1Faculty of Health Services, Beer-Sheva, Israel.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|July 27, 2005
PubMed
Summary

Maternal inflammatory bowel disease (IBD) is an independent risk factor for preterm delivery, but does not affect other perinatal outcomes. This study highlights key pregnancy outcomes for women with IBD.

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Area of Science:

  • Gastroenterology
  • Obstetrics & Gynecology
  • Reproductive Medicine

Background:

  • Inflammatory Bowel Disease (IBD) encompasses chronic conditions like Crohn's disease and ulcerative colitis.
  • Pregnancy in women with IBD requires careful consideration of maternal and fetal outcomes.
  • Understanding the impact of IBD on pregnancy is crucial for clinical management.

Purpose of the Study:

  • To investigate pregnancy outcomes in women diagnosed with Inflammatory Bowel Disease (IBD).
  • To assess the influence of pregnancy on the severity of IBD in affected mothers.
  • To identify specific risks associated with IBD during gestation.

Main Methods:

  • A case-control study design was employed, comparing deliveries of mothers with IBD to those without.

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  • Data were collected retrospectively between January 1988 and January 2005.
  • Controls were matched for ethnicity and delivery year, with a 1:4 ratio of IBD to non-IBD mothers.

    • Main Results:

    • Women with IBD experienced higher rates of preterm delivery (OR=2.2; 95% CI=1.3-3.8), an association confirmed by multivariate analysis (aOR=2.0; 95% CI=1.2-3.5).
    • Patients with IBD also showed increased utilization of fertility treatments (OR=2.2; 95% CI=1.1-4.4).
    • Perinatal outcomes, including mortality, Apgar scores, and congenital malformations, were comparable between IBD and control groups.

    Conclusions:

    • Maternal Inflammatory Bowel Disease is identified as an independent risk factor for preterm birth.
    • Pregnancy in women with IBD is not linked to adverse perinatal outcomes.
    • Clinical vigilance for preterm delivery is warranted in pregnant patients with IBD.