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Related Experiment Videos

Tim-2 regulates T helper type 2 responses and autoimmunity.

Sumone Chakravarti1, Catherine A Sabatos, Sheng Xiao

  • 1Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

The Journal of Experimental Medicine
|July 27, 2005
PubMed
Summary

Researchers identified Tim-2, a novel T cell molecule regulating immune responses. Blocking Tim-2 enhances T helper 2 (Th2) cell activity and reduces autoimmune disease severity, highlighting its role in inflammation.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • The T cell immunoglobulin mucin-domain containing (Tim) gene family regulates immune responses.
  • Tim-3 is expressed on T helper 1 (Th1) cells and controls Th1 immunity.
  • Tim-2 is a newly identified member of the Tim gene family.

Purpose of the Study:

  • To identify and characterize the function of Tim-2.
  • To investigate Tim-2's role in T helper 2 (Th2) cell regulation.
  • To explore Tim-2's therapeutic potential in autoimmune diseases.

Main Methods:

  • Gene identification and characterization.
  • Expression analysis in differentiated T helper cells.
  • Functional assays using soluble Tim-2 fusion protein (Tim-2 Ig).

Related Experiment Videos

  • Experimental autoimmune encephalomyelitis (EAE) model administration.

    • Main Results:

    • Tim-2 is preferentially expressed on differentiated Th2 cells.
    • Blockade of Tim-2/ligand interaction leads to T cell hyperproliferation and increased Th2 cytokine production.
    • Administration of Tim-2 Ig during induction phase ameliorates EAE severity.

    Conclusions:

    • Tim-2 is a critical regulator of Th2 immune responses.
    • Tim-2 plays a significant role in modulating autoimmune inflammation.
    • Tim-2 represents a potential therapeutic target for Th2-mediated autoimmune diseases.