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Related Experiment Videos

Relationship between HbA1c level and peripheral arterial disease.

Paul Muntner1, Rachel P Wildman, Kristi Reynolds

  • 1Department of Epidemiology, Tulane University SPHTM, 1430 Tulane Ave., SL-18 New Orleans, LA 70112, USA. pmuntner@tulane.edu

Diabetes Care
|July 27, 2005
PubMed
Summary

Higher hemoglobin A1c (HbA1c) levels are linked to peripheral arterial disease (PAD) risk, even in individuals without diabetes. Early intervention for those with HbA1c above 5.3% may mitigate cardiovascular risks.

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Area of Science:

  • Cardiovascular Health
  • Metabolic Disorders
  • Vascular Medicine

Background:

  • Homeostatic glucose control is implicated in peripheral arterial disease (PAD) development, particularly in non-diabetic individuals.
  • Understanding the role of glycated hemoglobin (HbA1c) in PAD is crucial for early detection and prevention.

Purpose of the Study:

  • To evaluate the association between HbA1c levels and PAD in a diverse U.S. population.
  • To determine if this association persists in individuals without diagnosed diabetes.

Main Methods:

  • Cross-sectional analysis of 4,526 participants (aged ≥40) from the National Health and Nutrition Examination Survey (1999-2002).
  • Peripheral arterial disease was identified using an ankle-brachial index <0.9.
  • Statistical analysis included multivariable adjustments.

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Main Results:

  • Among non-diabetic subjects, PAD prevalence increased with HbA1c levels (P trend <0.001).
  • Higher HbA1c levels (≥5.3%) were associated with increased odds of PAD in non-diabetic individuals.
  • Diabetic participants with HbA1c ≥7% had significantly higher odds of PAD compared to those with HbA1c <7%.

Conclusions:

  • Elevated HbA1c levels are associated with PAD, irrespective of diabetes status.
  • Targeting individuals with HbA1c ≥5.3% for aggressive risk factor reduction is recommended.
  • This approach may help reduce subclinical cardiovascular disease burden in pre-diabetic and diabetic populations.