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Updated: Aug 16, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Synthesis of cell-penetrating peptides for cargo delivery
1Estonian Biocentre, Tartu.
Abstract:
Cell-penetrating peptides (CPPs) have served as vehicles for the delivery of different molecules and particles into cells. The efficiency and noninvasive nature of peptide-mediated cellular transduction provides a promising tool for biomedical research. Studies of cell-penetrating constructs that deliver oligonucleotides, peptides, and proteins have elucidated several important cellular signaling mechanisms. Here we briefly describe the major classes of cell-penetrating peptides. We also present various strategies used to couple different cargoes to CPPs.
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