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Related Experiment Videos

[Drug tendon disorders].

Riadh Daghfous1, Sihem El Aidli, Refaat Gheni

  • 1Centre National de Pharmacovigilance, Sis Hôpital Charles Nicolle, Tunis.

La Tunisie Medicale
|July 28, 2005
PubMed
Summary
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Drug-induced tendinitis is a rare but serious adverse reaction. Fluoroquinolones and statins can cause tendinitis, particularly in older adults, necessitating cautious prescription.

Area of Science:

  • Pharmacology
  • Rheumatology
  • Adverse Drug Reactions

Context:

  • Tendinitis is an uncommon adverse drug reaction.
  • It is associated with specific drug classes, notably fluoroquinolones and statins.
  • The underlying pathophysiology remains largely unknown.

Purpose:

  • To review and report on drug-induced tendinitis.
  • To highlight the association between certain medications and tendinitis.
  • To emphasize the potential severity and need for caution in prescribing.

Summary:

  • Fluoroquinolones, especially pefloxacin, are frequently implicated in drug-induced tendinitis, predominantly affecting individuals over 60.
  • Approximately 20% of fluoroquinolone-associated tendinitis cases result in tendon rupture.

Related Experiment Videos

  • Tendinitis has also been reported with statins (e.g., simvastatin) in individuals over 50, with favorable outcomes after drug cessation.

    • Impact:

    • Drug-induced tendinitis can lead to severe consequences, including tendon rupture.
    • Physicians should exercise caution when prescribing medications like fluoroquinolones.
    • Awareness of this adverse reaction is crucial for patient safety and effective treatment.