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[Alpha interferon in children with Philadelphia chromosome-positive chronic myeloid-leukaemia]

Raihane Ben Lakhal1, Lamia Aissaoui, Ramzi Jeddi

  • 1Service d'hématologie de l'hôpital Aziza Othmana, Place du gouvernement la Kasba, Tunis.

La Tunisie Medicale
|July 28, 2005
PubMed

Insights

Alpha interferon demonstrated therapeutic efficacy in pediatric patients with chronic myeloid leukemia (CML), showing a complete hematologic response. This treatment was generally well-tolerated, offering a potential alternative to bone marrow transplantation for children with CML.

Area of Science:

  • Hematology
  • Pediatric Oncology
  • Pharmacology

Background:

  • Chronic myeloid leukemia (CML) in pediatric patients requires effective and tolerable treatment options.
  • Hydroxyurea was used as an initial therapy for all patients.
  • Alpha interferon was administered after a median of 8 months of hydroxyurea treatment.

Observation:

  • Five pediatric patients with CML were treated with alpha interferon between 1990 and 1999.
  • Treatment involved alpha interferon at 5 million units/m2.
  • Patients were followed up for therapeutic efficacy and toxicity.

Findings:

  • All patients achieved a complete hematologic response six months after initiating alpha interferon therapy.
  • The median overall survival was 66 months, with three patients still alive.
  • Common side effects included mild symptoms like asthenia and fever; myelosuppression occurred in two patients.

Implications:

  • Alpha interferon is well-tolerated in pediatric CML patients and may serve as an alternative to bone marrow transplantation for those in the chronic phase without a donor.
  • Further evaluation of novel agents like STI 571 is warranted for pediatric CML treatment.

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