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Related Experiment Videos

Estimating medication persistency using administrative claims data.

Rishi Sikka1, Fang Xia, Ronald E Aubert

  • 1Department of Medical Affairs, Medco Health Solutions, Franklin Lakes, NJ 07417, USA.

The American Journal of Managed Care
|July 28, 2005
PubMed
Summary
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Measuring medication persistency is key to understanding patient adherence. Analyzing gaps between prescription refills offers the most accurate assessment of medication refill compliance for chronic therapies.

Area of Science:

  • Pharmacoeconomics and Health Outcomes Research
  • Pharmacoepidemiology
  • Health Services Research

Background:

  • Medication persistency, or adherence to chronic drug therapy, is crucial for effective treatment outcomes.
  • Current methods for measuring medication persistency lack uniformity, hindering comparative analysis.
  • Pharmacy claims data offer a valuable resource for assessing medication usage patterns.

Purpose of the Study:

  • To conduct a comprehensive literature review of existing definitions and measurement methods for medication persistency.
  • To propose a standardized definition and calculation for medication persistency using pharmacy claims data.

Main Methods:

  • A systematic literature search of MEDLINE (1966–present) was conducted to identify relevant articles.

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  • Articles were screened for relevance based on title and abstract.
  • References from identified articles were reviewed to broaden the search scope.

    • Main Results:

    • Medication persistency measurement aims to quantify the duration of an individual's adherence to chronic drug therapy.
    • Existing calculation methods fall into three main categories: medication possession ratio, medication availability at a fixed point, and gaps between refills.
    • Each method provides a different perspective on patient adherence to prescribed medications.

    Conclusions:

    • The primary objective of medication persistency measures should be to reflect the continuity and timeliness of medication refills.
    • Measuring persistency based on the gaps between refills provides the most robust assessment of refill compliance.
    • This approach is adaptable across diverse medication and disease states and aligns with survival analysis methodologies.