Related Experiment Video
Updated: Aug 16, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
Dyschromatosis universalis hereditaria: two cases in a Chinese family
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an China. xjwgang@fmmu.edu.cn
Abstract:
Two cases of dyschromatosis universalis hereditaria (DUH) from a Chinese family are presented. Case 1 was a 62-year-old woman who had a generalized and progressive hyper- and hypopigmentation of the skin from the age of 8 years. Her brother had also developed a similar skin pigmentary defect from about the same age. Histopathological and ultrastructural examination of lesional skin showed increased melanin content in epidermal keratinocytes but no changes in the appearance or number of melanocytes. Although hereditary defects may influence melanogenesis resulting in a pigmentary anomaly, the pathogenesis of DUH remains unclear.
More Related Videos
Related Concept Videos
Pleiotropy
Pedigree Analysis
Genetic Lingo
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Sex-linked Disorders
X-linked Traits

