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Persistent severe amiodarone-induced photosensitivity.
S S Yones1, N B O'Donoghue, R A Palmer
1Photobiology Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK. Sami.yones@kcl.ac.uk
Clinical and Experimental Dermatology
|July 28, 2005
Summary
Amiodarone can cause skin discoloration and photosensitivity. While discoloration usually fades, this patient experienced persistent photosensitivity for over 17 years after stopping the drug.
Area of Science:
- Pharmacology
- Dermatology
- Cardiology
Background:
- Amiodarone, a benzofuran derivative, is an antiarrhythmic and coronary vasodilator.
- Common side effects include cutaneous photosensitivity.
- Rarely, slate-grey or violaceous dyspigmentation occurs after prolonged use.
Observation:
- A patient developed photosensitivity and slate-grey discoloration while on amiodarone.
- The dyspigmentation resolved after drug discontinuation.
- However, photosensitivity persisted for over 17 years.
Findings:
- Amiodarone-induced dyspigmentation is typically reversible.
- Cutaneous photosensitivity from amiodarone can be a long-lasting side effect.
- This case highlights prolonged photosensitivity despite drug cessation.
Implications:
- Clinicians should be aware of the potential for persistent photosensitivity with amiodarone.
- Long-term monitoring for dermatological side effects may be necessary.
- Further research into the mechanisms of persistent amiodarone-induced photosensitivity is warranted.