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Related Experiment Videos

Persistent severe amiodarone-induced photosensitivity.

S S Yones1, N B O'Donoghue, R A Palmer

  • 1Photobiology Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK. Sami.yones@kcl.ac.uk

Clinical and Experimental Dermatology
|July 28, 2005
PubMed
Summary
This summary is machine-generated.

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Amiodarone can cause skin discoloration and photosensitivity. While discoloration usually fades, this patient experienced persistent photosensitivity for over 17 years after stopping the drug.

Area of Science:

  • Pharmacology
  • Dermatology
  • Cardiology

Background:

  • Amiodarone, a benzofuran derivative, is an antiarrhythmic and coronary vasodilator.
  • Common side effects include cutaneous photosensitivity.
  • Rarely, slate-grey or violaceous dyspigmentation occurs after prolonged use.

Observation:

  • A patient developed photosensitivity and slate-grey discoloration while on amiodarone.
  • The dyspigmentation resolved after drug discontinuation.
  • However, photosensitivity persisted for over 17 years.

Findings:

  • Amiodarone-induced dyspigmentation is typically reversible.
  • Cutaneous photosensitivity from amiodarone can be a long-lasting side effect.
  • This case highlights prolonged photosensitivity despite drug cessation.

Related Experiment Videos

Implications:

  • Clinicians should be aware of the potential for persistent photosensitivity with amiodarone.
  • Long-term monitoring for dermatological side effects may be necessary.
  • Further research into the mechanisms of persistent amiodarone-induced photosensitivity is warranted.