Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ligament tissue engineering: an evolutionary materials science approach.

Cato T Laurencin1, Joseph W Freeman

  • 1Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA 22903, USA. ctl3f@virginia.edu

Biomaterials
|July 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanofiber based transformative approaches for tendon regenerative engineering: past, present and future.

Nanomedicine (London, England)·2026
Same author

Magnesium phosphate functionalized graphene oxide and PLGA composite matrices with enhanced mechanical and osteogenic properties for bone regeneration.

Regenerative biomaterials·2025
Same author

Osteoinductive low-dose 3D porous calcium phosphate graphene oxide-integrated matrices enhance osteogenesis and mechanical properties.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Graphene Oxide in Bone Regenerative Engineering: Current Challenges and Future Perspectives.

ACS bio & med chem Au·2025
Same author

A novel protocol for the direct isolation of a highly pure and regenerative population of satellite stem cells.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Fat Expansion Not Fat Infiltration of Muscle Post Rotator Cuff Tendon Tears of the Shoulder: Regenerative Engineering Implications.

Regenerative engineering and translational medicine·2025
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
Same journal

Mg-integrated octopus-inspired hydrogel dressing enables autonomous adhesion and wound closure for enhanced healing via sequential microenvironment regulation.

Biomaterials·2026
Same journal

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
Same journal

Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

Biomaterials·2026
Same journal

An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

Biomaterials·2026
Same journal

Peptide coacervate-mediated siRNA delivery for dual PD-1/PD-L1 blockade to enhance colorectal cancer immunotherapy.

Biomaterials·2026
See all related articles

Tissue-engineered scaffolds aim to regenerate the anterior cruciate ligament (ACL), a commonly injured knee ligament with poor natural healing. These innovative solutions seek to restore knee stability by mimicking natural ligament properties.

Area of Science:

  • Biomedical Engineering
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • The anterior cruciate ligament (ACL) is crucial for knee joint stability.
  • ACL injuries are common and result in poor healing due to limited vascularization.
  • Existing ACL replacement methods have significant limitations, driving the need for alternatives.

Purpose of the Study:

  • To explore tissue-engineered solutions for anterior cruciate ligament (ACL) repair.
  • To develop scaffolds that promote ligament regeneration and restore mechanical function.
  • To overcome the limitations of current ACL reconstruction techniques.

Main Methods:

  • Investigating various scaffold materials, including silk and poly (L-lactic acid) fibers.
  • Designing scaffolds with specific architectures, such as twisted fibers and 3D braided structures.

Related Experiment Videos

  • Exploring the incorporation of porous scaffolds, cells, and growth factors to enhance regeneration.

    • Main Results:

    • Development of diverse tissue-engineered scaffolds for ACL repair.
    • Focus on creating constructs that mimic the mechanical properties of native ACL tissue.
    • Research into strategies to improve the healing and regenerative capacity of the ACL.

    Conclusions:

    • Tissue engineering offers promising avenues for ACL reconstruction.
    • Scaffold design and biomaterial choice are critical for successful ligament regeneration.
    • Future solutions aim to provide functional and durable ACL replacements.