Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts.

Evelyne van Etten1, Chantal Mathieu

  • 1Laboratory of Experimental Medicine and Endocrinology (LEGENDO), Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium.

The Journal of Steroid Biochemistry and Molecular Biology
|July 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes.

Diabetes/metabolism research and reviews·2024
Same author

The Health Economics of Automated Insulin Delivery Systems and the Potential Use of Time in Range in Diabetes Modeling: A Narrative Review.

Diabetes technology & therapeutics·2024
Same author

The double burden: Navigating type 1 diabetes and obesity.

Clinical obesity·2024
Same author

An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes.

Diabetes·2024
Same author

Cost-utility analysis of Dexcom G6 real-time continuous glucose monitoring versus FreeStyle Libre 1 intermittently scanned continuous glucose monitoring in adults with type 1 diabetes in Belgium.

Diabetologia·2024
Same author

Hypoglycaemia after Initiation of CFTR Modulator Therapy in a Cystic Fibrosis Patient without Diabetes.

Case reports in endocrinology·2024

1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) modulates the immune system by targeting dendritic cells, inhibiting T cell activation. This vitamin D metabolite shows promise for treating autoimmune diseases and preventing transplant rejection.

Area of Science:

  • Immunology
  • Endocrinology
  • Molecular Biology

Background:

  • 1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is the active form of Vitamin D(3).
  • It regulates calcium and bone metabolism and has immunomodulatory functions.
  • The Vitamin D receptor (VDR) is present on immune cells like antigen-presenting cells and T cells.

Purpose of the Study:

  • To investigate the immunomodulatory effects of 1,25(OH)(2)D(3).
  • To explore its potential in autoimmune diseases and transplantation.

Main Methods:

  • Studied the effects of 1,25(OH)(2)D(3) on dendritic cell differentiation and maturation.
  • Assessed the impact on T cell activation.
  • Examined the in vivo efficacy in autoimmune and transplantation models.

Related Experiment Videos

Main Results:

  • 1,25(OH)(2)D(3) inhibits dendritic cell maturation and down-regulates MHC-II, costimulatory molecules, and IL-12.
  • It enhances IL-10 production and promotes dendritic cell apoptosis, inhibiting T cell activation.
  • In vivo studies demonstrated immunomodulation in autoimmune disease and transplantation models.

Conclusions:

  • 1,25(OH)(2)D(3) possesses significant immunomodulatory properties.
  • Analogs of 1,25(OH)(2)D(3) may offer therapeutic potential for autoimmune diseases and allograft rejection.
  • Non-hypercalcemic analogs could be clinically useful for immune modulation.