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Related Experiment Videos

CXC chemokines in angiogenesis.

Robert M Strieter1, Marie D Burdick, Brigitte N Gomperts

  • 1Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90095-1786, USA. rstrieter@mednet.ucla.edu

Cytokine & Growth Factor Reviews
|July 28, 2005
PubMed
Summary

CXC chemokines regulate blood vessel growth (angiogenesis) differently. Some promote it via CXCR2, while others inhibit it via CXCR3, impacting various diseases.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • CXC chemokines are cytokines with diverse roles in immunity, cancer metastasis, and angiogenesis.
  • They exhibit dual functions in regulating blood vessel formation.
  • This duality is linked to the presence or absence of the 'ELR' motif.

Purpose of the Study:

  • To review the biology of CXC chemokines involved in angiogenesis.
  • To discuss their opposing roles as angiogenic promoters and inhibitors.
  • To explore their involvement in various disease contexts.

Main Methods:

  • Literature review of studies on CXC chemokines and angiogenesis.
  • Analysis of the role of the 'ELR' motif in chemokine function.
  • Examination of receptor interactions (CXCR2 and CXCR3) on endothelial cells.

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Main Results:

  • ELR-motif containing CXC chemokines promote angiogenesis via CXCR2.
  • ELR-negative CXC chemokines inhibit angiogenesis via CXCR3.
  • These opposing activities are crucial in various pathological conditions.

Conclusions:

  • CXC chemokines represent a critical regulatory axis in angiogenesis.
  • Their distinct functions via CXCR2 and CXCR3 have significant implications for disease.
  • Understanding these mechanisms offers therapeutic potential for angiogenesis-related disorders.