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Hybrid chromophobe renal cell neoplasm
Kien T Mai1, Prashant Dhamanaskar, Eric Belanger
1Division of Anatomical Pathology, Department of Laboratory Medicine, The Ottawa Hospital-Civic Campus, 1053 Carling Avenue, Ottawa, Ont., Canada, K1Y 4E9. ktmai@ottawahospital.on.ca
Pathology, Research and Practice
|July 29, 2005
Summary
Sporadic hybrid renal cell neoplasms (HRCNs) are rare tumors combining chromophobe renal cell carcinoma and renal oncocytoma features. These tumors, distinct from Birt-Hogg-Dube syndrome, show a favorable prognosis.
Area of Science:
- Uropathology
- Oncology
- Genetics
Background:
- Hybrid renal cell neoplasms (HRCNs) with chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO) features are recently described.
- These tumors have been associated with renal oncocytosis and Birt-Hogg-Dube (BHD) syndrome.
Purpose of the Study:
- To identify and characterize sporadic cases of HRCN.
- To differentiate sporadic HRCN from BHD-associated HRCN.
Main Methods:
- Review of 425 consecutive renal cell carcinomas (RCC), 18 CHRCC, six HRCN, and 25 RO.
- Histopathological and immunohistochemical analysis (Hale's colloidal iron, cytokeratin 7, vimentin).
Main Results:
- Five sporadic HRCNs were identified, accounting for 1% of RCC.
- Tumors occurred in patients aged 40-68 years (mean 54), male:female ratio 4:1.
- Sporadic HRCNs were smaller than typical RCC and lacked necrosis or association with BHD syndrome.
Conclusions:
- Sporadic HRCN is a distinct entity from BHD-associated HRCN.
- These tumors exhibit a favorable prognosis.
- Further research is needed to understand the specific characteristics and behavior of sporadic HRCN.