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Related Experiment Videos

[Dementia with Lewy bodies].

Kenji Kosaka1, Eizo Iseki, Takashi Togo

  • 1Department of Psychiatry, Yokohama City University School of Medicine.

Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica
|July 29, 2005
PubMed
Summary

Dementia with Lewy bodies (DLB) has gained recognition as a major dementia since its proposal in 1995. This review covers DLB's history, diagnosis, and scientific aspects.

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Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Context:

  • Dementia with Lewy bodies (DLB) emerged as a distinct clinical entity in the 1980s and 1990s.
  • DLB is now recognized as one of the three major dementing illnesses, alongside Alzheimer's disease and vascular dementia.
  • International workshops have refined diagnostic criteria since 1995, with revised guidelines forthcoming.

Purpose:

  • To provide a comprehensive review of Dementia with Lewy bodies (DLB).
  • To consolidate historical, clinical, therapeutic, and neuropathological information on DLB.
  • To highlight key developments and ongoing research in DLB.

Summary:

  • This article reviews the history of Dementia with Lewy bodies (DLB) since its initial proposal.
  • It covers the evolution of diagnostic criteria, clinical features, and therapeutic approaches.
  • Neuropathological, neurochemical, and molecular biological aspects of DLB are also discussed, referencing seminal works and recent reports.

Impact:

  • DLB is now a recognized major cause of dementia, influencing clinical practice and research.
  • The ongoing refinement of diagnostic criteria aids in earlier and more accurate diagnosis.
  • This review serves as a foundational resource for understanding DLB and advancing future research and treatment strategies.

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