Related Experiment Video

Updated: Aug 16, 2026

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses
14:05

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses

Published on: January 23, 2017

Sodium sieving in children

Esther Rusthoven1, Raymond T Krediet, Hans L Willems

  • 1Department of Pediatric Nephrology and Dialysis, University Medical Center, Utrecht, The Netherlands. erusthoven@xs4all.nl

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|July 29, 2005
PubMed

Insights

Sodium sieving, a measure of aquaporin-mediated water transport, is absent with icodextrin. This indicates icodextrin is suitable for peritoneal dialysis in children, offering effective ultrafiltration.

Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Physiology

Background:

  • Sodium sieving, the dissociation of water and sodium transport across the peritoneal membrane, is linked to aquaporin-mediated water transport.
  • This phenomenon can serve as an indicator of aquaporin activity during peritoneal dialysis.

Purpose of the Study:

  • To evaluate the role of aquaporins in ultrafiltration using icodextrin during peritoneal dialysis.
  • To assess the suitability of icodextrin for daytime dwells in children undergoing intermittent peritoneal dialysis.

Main Methods:

  • Investigating sodium sieving as a marker for aquaporin-mediated water transport.
  • Comparing ultrafiltration efficacy of icodextrin with 3.86% glucose in a pediatric cohort.

Main Results:

  • The absence of sodium sieving was observed when using icodextrin, suggesting a minor role for aquaporins in icodextrin-induced ultrafiltration.
  • Icodextrin demonstrated ultrafiltration comparable to 3.86% glucose after a 12-hour dwell.
  • Findings were consistent in pediatric patients, reinforcing the limited involvement of aquaporins.

Conclusions:

  • Icodextrin is a suitable osmotic agent for daytime peritoneal dialysis dwells in children on intermittent peritoneal dialysis regimens.
  • The lack of sodium sieving confirms that aquaporins play a minimal role in the ultrafiltration process driven by icodextrin.

More Related Videos

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults09:17

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults

Published on: July 16, 2016

Caenorhabditis Sieve: A Low-tech Instrument and Methodology for Sorting Small Multicellular Organisms04:39

Caenorhabditis Sieve: A Low-tech Instrument and Methodology for Sorting Small Multicellular Organisms

Published on: July 4, 2018

Related Concept Videos

Roles of Electrolytes: Sodium and Potassium01:24

Roles of Electrolytes: Sodium and Potassium

Sodium plays a crucial role in maintaining fluid and electrolyte balance and overall bodily homeostasis. Sodium balance is primarily regulated by kidney function, which adjusts sodium elimination to match dietary intake and maintain proper electrolyte levels. Sodium is the most abundant cation in the extracellular fluid (ECF) and is found in salts such as sodium chloride (NaCl) and sodium bicarbonate (NaHCO3). Although cellular plasma membranes are relatively impermeable to sodium, its role in...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Ionic Strength: Effects on Chemical Equilibria01:19

Ionic Strength: Effects on Chemical Equilibria

The addition of an inert ionic compound increases the solubility of a sparingly soluble salt. For example, adding potassium nitrate to a saturated solution of calcium sulfate significantly enhances the solubility of calcium sulfate. Le Châtelier's principle cannot predict this shift in the equilibrium. Instead, this could be explained in terms of changes in the effective concentration of the ions in solution in the presence of added inert salt.
In this solution, the primary cation—the calcium...