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Related Experiment Videos

Sodium sieving in children.

Esther Rusthoven1, Raymond T Krediet, Hans L Willems

  • 1Department of Pediatric Nephrology and Dialysis, University Medical Center, Utrecht, The Netherlands. erusthoven@xs4all.nl

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|July 29, 2005
PubMed
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Sodium sieving, a measure of aquaporin-mediated water transport, is absent with icodextrin. This indicates icodextrin is suitable for peritoneal dialysis in children, offering effective ultrafiltration.

Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Physiology

Background:

  • Sodium sieving, the dissociation of water and sodium transport across the peritoneal membrane, is linked to aquaporin-mediated water transport.
  • This phenomenon can serve as an indicator of aquaporin activity during peritoneal dialysis.

Purpose of the Study:

  • To evaluate the role of aquaporins in ultrafiltration using icodextrin during peritoneal dialysis.
  • To assess the suitability of icodextrin for daytime dwells in children undergoing intermittent peritoneal dialysis.

Main Methods:

  • Investigating sodium sieving as a marker for aquaporin-mediated water transport.
  • Comparing ultrafiltration efficacy of icodextrin with 3.86% glucose in a pediatric cohort.

Main Results:

Related Experiment Videos

  • The absence of sodium sieving was observed when using icodextrin, suggesting a minor role for aquaporins in icodextrin-induced ultrafiltration.
  • Icodextrin demonstrated ultrafiltration comparable to 3.86% glucose after a 12-hour dwell.
  • Findings were consistent in pediatric patients, reinforcing the limited involvement of aquaporins.

Conclusions:

  • Icodextrin is a suitable osmotic agent for daytime peritoneal dialysis dwells in children on intermittent peritoneal dialysis regimens.
  • The lack of sodium sieving confirms that aquaporins play a minimal role in the ultrafiltration process driven by icodextrin.