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Updated: Jul 24, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
10:42

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

A scalable route to trisubstituted (E)-vinyl bromides.

Cheon-Gyu Cho1, Won-Suk Kim, Amos B Smith

  • 1Department of Chemistry, Hanyang University, Seoul, Korea 133-791. ccho@hanyang.ac.kr

Organic Letters
|July 29, 2005
PubMed
Summary

A new two-step synthesis efficiently creates trisubstituted (E)-vinyl bromides from unsaturated lactones. This scalable method yields key intermediates for complex natural products like tedanolide.

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