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Updated: May 5, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space

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Published on: July 17, 2009

Aging and gene expression in the primate brain.

Hunter B Fraser¹, Philipp Khaitovich, Joshua B Plotkin

¹Department of Molecular and Cell Biology, University of California, Berkeley, California, USA. hunter@alum.mit.edu

|July 29, 2005

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Gene expression changes with aging differ across human brain regions and between humans and chimpanzees. These findings highlight the diversity of aging and its evolution, impacting neurodegeneration research.

Area of Science:

Genomics
Neuroscience
Evolutionary Biology

Background:

Gene expression patterns change during aging across organisms.
DNA microarrays enable genome-wide studies of age-related transcriptional changes.
Understanding brain aging is crucial for neurodegenerative disease research.

Purpose of the Study:

To investigate age-related gene expression alterations in the human cerebral cortex and cerebellum.
To compare these patterns with age-related changes in chimpanzee cortex.
To explore the diversity and evolutionary aspects of brain aging.

Main Methods:

Utilized DNA microarrays for genome-wide gene expression analysis.
Compared transcriptional changes associated with aging in human cerebral cortex, human cerebellum, and chimpanzee cortex.

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Last Updated: May 5, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space

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Published on: July 17, 2009

Brain Banking: Making the Most of your Research Specimens

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Published on: July 24, 2009

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

Analyzed patterns of age-related gene expression alterations.

Main Results:

Human cerebral cortex shows more consistent age-related gene expression changes than the cerebellum.
Chimpanzee cortex exhibits distinct age-related gene expression patterns compared to human cortex.
Significant differences in aging patterns were observed within the human brain and across species.

Conclusions:

Aging affects gene expression diversely across human brain regions.
Genome-wide aging patterns evolve rapidly between species, as seen in human and chimpanzee cortex.
Findings may inform the oxidative free radical theory of aging and neurodegenerative disease understanding.