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Related Experiment Videos

Computational simulation of the blood separation process.

Sandro De Gruttola1, Kevin Boomsma, Dimos Poulikakos

  • 1Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland.

Artificial Organs
|July 29, 2005
PubMed
Summary
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This study developed a computational fluid dynamics model to simulate apheresis, successfully separating blood components like plasma, red blood cells, and platelets. The model accurately predicts component separation and white blood cell behavior.

Area of Science:

  • Biomedical Engineering
  • Computational Science
  • Fluid Dynamics

Background:

  • Apheresis is a medical procedure to separate blood components.
  • Simulating the complex fluid dynamics of apheresis is crucial for optimizing separation efficiency.
  • Existing models may not fully capture the quasitransient nature of the process.

Purpose of the Study:

  • To develop a computational fluid dynamics (CFD) model for simulating the quasitransient apheresis process.
  • To validate the model's ability to predict the behavior and separation of blood components.

Main Methods:

  • A two-dimensional Lagrangian-Eulerian model was developed.
  • Eulerian method solved fluid flow conservation equations within the separator.
  • Lagrangian method tracked blood particle displacement to determine local blood density.

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  • Iterative recalculation of the flow field until quasisteady behavior was achieved.

    • Main Results:

    • Simulations demonstrated good agreement with experimental results.
    • The model achieved complete separation of plasma and red blood cells.
    • Nearly complete separation of red blood cells and platelets was observed.
    • White blood cells were shown to form clusters in the low concentrate cell bed.

    Conclusions:

    • The developed CFD model accurately simulates the quasitransient apheresis process.
    • The model provides valuable insights into blood component separation dynamics.
    • This computational approach can aid in the design and optimization of apheresis devices.