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Updated: Aug 16, 2026

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
Published on: July 26, 2019
Development of intestinal M cells
Julie Mach1, Tammy Hshieh, Dennis Hsieh
1The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Abstract:
Intestinal epithelium contains several specialized cell types including M cells, which can be found in the follicle-associated epithelium (FAE) or occasionally on the villi. M cells are critical for sampling of intestinal flora and for transferring pathogens across the epithelial barrier for recognition by the immune system. Development of M cells on the villi (M(v)) is independent of the presence of lymphocytes, while development of the FAE and M cells within the FAE (M(f)) is dependent on B lymphocytes. Here, the concept is discussed that B cells are not required for induction of M(f) differentiation but are required for transition to and maintenance of the mature M(f) phenotype. Signaling pathways possibly involved in the B-cell-independent stages of M-cell development are also discussed.
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