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Lymphoma with large-plaque parapsoriasis treated with PUVA
Risa Tamagawa1, Norito Katoh, Chihiro Shimazaki
1Department of Dermatology, Department of Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science. 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan. risat@koto.kpu-m.ac.jp
European Journal of Dermatology : EJD
|July 29, 2005
Summary
A long-term case of large-plaque parapsoriasis evolved into CD30+ cutaneous T-cell lymphoma in an elderly woman. Successful treatment with chemotherapy led to remission without recurrence.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Large-plaque parapsoriasis is a rare, chronic skin condition.
- Cutaneous T-cell lymphoma (CTCL) can arise from pre-existing dermatoses.
- Long-term ultraviolet A (UVA) therapy is a potential risk factor for skin malignancies.
Observation:
- A 78-year-old woman with a 50-year history of large-plaque parapsoriasis developed an isolated nodule.
- The nodule lacked associated patches or plaques, presenting atypically.
- Histopathology showed a dermal infiltrate of atypical large lymphocytes.
Findings:
- The patient was diagnosed with CD30+ cutaneous large T-cell lymphoma.
- The lymphoma was suspected to have evolved from the long-standing parapsoriasis.
- The patient responded well to systemic chemotherapy.
Implications:
- This case highlights the potential evolution of parapsoriasis into CTCL.
- It underscores the importance of vigilant monitoring for atypical presentations in chronic skin conditions.
- Early diagnosis and treatment of CTCL are crucial for favorable outcomes.