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Related Experiment Videos

Pathogen adaptation under imperfect vaccination: implications for pertussis.

Michiel van Boven1, Frits R Mooi, Joop F P Schellekens

  • 1Animal Sciences Group, Wageningen University and Research Centre, PO Box 65, 8200 AB Lelystad, The Netherlands. michielvanboven@wur.nl

Proceedings. Biological Sciences
|July 29, 2005
PubMed
Summary

Vaccine effectiveness against infectious diseases like pertussis can be limited. Imperfect vaccines may fail if secondary infections spread easily, impacting pathogen evolution and population dynamics.

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Area of Science:

  • Epidemiology
  • Evolutionary Biology
  • Immunology

Background:

  • Mass vaccination campaigns have historically reduced infectious disease burdens.
  • Recent re-emergence of diseases like pertussis highlights challenges in disease control.
  • Understanding pathogen dynamics under vaccination pressure is crucial.

Purpose of the Study:

  • To investigate the population and evolutionary dynamics of pathogens under vaccination pressure using an epidemic model.
  • To analyze the impact of imperfect vaccines on infection dynamics.
  • To explore conditions favoring the spread of immune-evading pathogen strains.

Main Methods:

  • Development and analysis of an epidemic model.
  • Distinction between primary (naive) and secondary (primed) infections.

Related Experiment Videos

  • Modeling pathogen evolution under vaccine-induced selective pressure.

    • Main Results:

    • Imperfect vaccines may not reduce infection pressure if secondary infections are more transmissible.
    • Immune-evading pathogen strains can spread if they have minimal fitness costs.
    • Evolutionary trajectory depends on the distribution of susceptible individuals in the population.

    Conclusions:

    • Vaccine design and deployment strategies need to consider pathogen transmissibility and immune evasion.
    • The duration of vaccine-induced immunity and its impact on population susceptibility are critical factors.
    • Findings have implications for managing vaccine-preventable diseases and preventing pathogen evolution.