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Published on: February 23, 2014
Molecular characterization of the first telithromycin-resistant Streptococcus pneumoniae isolate in Germany
Ralf René Reinert1, Mark van der Linden, Adnan Al-Lahham
1Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, D-52057 Aachen, Germany. Reinert@rwth-aachen.de
Abstract:
A total of 486 Streptococcus pneumoniae isolates were collected in 2003 and 2004 in Germany and revealed the following resistance rates: penicillin G (7.2%) and erythromycin A (18.9%). Telithromycin exhibited good in vitro activity (MIC at which 90% of the isolates tested were inhibited, 0.125 microg/ml). However, one erm(B)-positive isolate was found to be telithromycin resistant (MIC, 8 microg/ml).
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