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Updated: Jun 23, 2026

Experimental Metastasis Assay
Published on: August 25, 2010
Genes that mediate breast cancer metastasis to lung
Andy J Minn1, Gaorav P Gupta, Peter M Siegel
1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Abstract:
By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.
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