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[Painful cutaneous leiomyosarcoma].

C Mitteldorf1, H P Bertsch, L Kretschmer

  • 1Hautklinik und Poliklinik der Georg-August-Universität Göttingen, Göttingen. Christina.Mitteldorf@gmx.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|July 29, 2005
PubMed
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Cutaneous leiomyosarcomas rarely involve the skin. This study details a painful chest tumor in a 73-year-old male, revealing entrapped nerves, unlike previously studied painless cases.

Area of Science:

  • Dermatology
  • Surgical Pathology
  • Oncology

Background:

  • Leiomyosarcomas, tumors originating from smooth muscle, infrequently manifest in the skin.
  • Cutaneous leiomyosarcomas are typically painless, aiding in differential diagnosis from benign leiomyomas.

Observation:

  • A 73-year-old male presented with a 3-year history of a progressively painful chest tumor.
  • The tumor was tender to palpation, a characteristic more commonly associated with benign leiomyomas.
  • Histopathological examination revealed atypical myofibrils entrapping multiple nerve fibers within the tumor.

Findings:

  • Immunohistochemical staining confirmed the presence of entrapped nerve fibers, offering a potential explanation for the tumor's tenderness.
  • This finding contrasts with five previously excised painless cutaneous leiomyosarcomas, which lacked evidence of nerve entrapment.

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Implications:

  • The presence of entrapped nerves in cutaneous leiomyosarcomas may correlate with clinical symptoms like pain and tenderness.
  • This case highlights the importance of considering nerve involvement in the presentation and diagnosis of cutaneous smooth muscle tumors.
  • Further research is warranted to understand the pathobiology of nerve-tumor interactions in leiomyosarcomas.