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Concise total syntheses of variolin B and deoxyvariolin B
Regan J Anderson1, Jonathan B Hill, Jonathan C Morris
1Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Abstract:
The total synthesis of the marine alkaloid variolin B has been achieved in 8 steps and 17% overall yield, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid. In addition, the deoxygenated analogue was prepared in 6 steps and 23% overall yield, starting from the same starting material.
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