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Updated: Aug 16, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
Sequential Pd(II)-Pd(0) catalysis for the rapid synthesis of coumarins
Kelin Li1, Yibin Zeng, Ben Neuenswander
1Department of Chemistry, 1251 Wescoe Hall Drive, 2010 Malott Hall, University of Kansas, Lawrence, Kansas 66045-7582, USA.
Abstract:
Electrophilic palladium-catalyzed cycloisomerization of brominated aryl propiolates produces brominated coumarins. The brominated coumarins can be diversified by reduction of the Pd(II) catalyst to Pd(0) followed by Suzuki, Sonogashira, Heck, or Hartwig-Buchwald coupling. Thus, a single loading of precatalyst can be used to conduct sequential reactions, allowing the synthesis of functionalized coumarins. Extension of this methodology toward the synthesis of coumarin libraries is discussed.
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