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Optimized Protocol for Efficient Transfection of Dendritic Cells without Cell Maturation
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Activation of antigen-presenting cells by DNA delivery vectors

Wilson S Meng1, Lisa H Butterfield

  • 1Duquesne University, Division of Pharmaceutical Sciences, 600 Forbes Ave, Pittsburgh, PA 15282, USA. meng@duq.edu

Expert Opinion on Biological Therapy
|July 30, 2005
PubMed

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T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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