Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Problems related to dorsal root entry zone lesions.

Y Kumagai1, K Shimoji, T Honma

  • 1Department of Anesthesiology, Niigata University School of Medicine, Japan.

Acta Neurochirurgica
|January 1, 1992
PubMed
Summary

Dorsal root entry zone lesions (DREZLs) provided significant initial pain relief for chronic pain patients, but effectiveness waned over time. Complications like sensory loss and new pain were observed, highlighting the need for precise surgical technique.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytomegalovirus ventriculoencephalitis in a reduced- intensity conditioning cord blood transplant recipient.

Transplant infectious disease : an official journal of the Transplantation Society·2010
Same author

Cerebellar lesions in multiple system atrophy: postmortem MR imaging-pathologic correlations.

AJNR. American journal of neuroradiology·2009
Same author

Functional prognosis after treatment of spinal dural arteriovenous fistulas.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2008
Same author

Cerebral cortical and white matter lesions in amyotrophic lateral sclerosis with dementia: correlation with MR and pathologic examinations.

AJNR. American journal of neuroradiology·2007
Same author

Wallerian degeneration of the corticospinal tracts: postmortem MR-pathologic correlations.

Acta radiologica (Stockholm, Sweden : 1987)·2007
Same author

Hyperintense putaminal rim at 3T reflects fewer ferritin deposits in the lateral marginal area of the putamen.

AJNR. American journal of neuroradiology·2007

Area of Science:

  • Neurosurgery
  • Pain Management
  • Neurology

Background:

  • Chronic pain management presents significant clinical challenges.
  • Dorsal root entry zone lesions (DREZLs) are a surgical intervention for intractable pain.
  • Understanding the efficacy and complications of DREZLs is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the clinical outcomes of DREZLs in patients with chronic pain.
  • To assess pain relief, complications, and correlate subjective and objective pain scores.
  • To analyze postmortem histological findings to refine surgical techniques.

Main Methods:

  • Retrospective analysis of 15 patients undergoing DREZLs.
  • Assessment of subjective pain relief and development of an objective pain relief score.

Related Experiment Videos

  • Documentation of sensory and motor complications.
  • Histopathological examination of spinal cord tissue in two cases.

    • Main Results:

    • Most patients (13/15) experienced over 70% subjective pain relief initially, which decreased during follow-up.
    • A significant positive correlation was found between subjective and objective pain relief scores, with some discrepancies.
    • Complications included sensory loss (12 patients), motor weakness (7), paresthesia (4), and new pain (6).
    • Postmortem histology emphasized avoiding coagulation beyond the dorsal horn.

    Conclusions:

    • DREZLs offer initial pain relief for chronic pain but may have limited long-term efficacy.
    • Careful surgical technique is essential to minimize neurological deficits and complications.
    • Further research into optimizing DREZLs and managing complications is warranted.