Related Experiment Video

Updated: Aug 16, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Small cell carcinoma of epididymis: multimodal therapy

Guilherme C Lima1, Ioannis M Varkarakis, Mohamad E Allaf

  • 1James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. guilolima@terra.com.br

Urology
|July 30, 2005
PubMed

Insights

Extrapulmonary small cell carcinoma is rare, with limited data on its clinical course. This case highlights multimodal therapy for aggressive small cell carcinoma of the epididymis with retroperitoneal recurrence.

Area of Science:

  • Oncology
  • Urologic Oncology

Background:

  • Extrapulmonary small cell carcinoma (EPSCC) is a rare malignancy with diverse origins.
  • Limited information exists regarding the clinical characteristics, treatment strategies, and prognosis of EPSCC.

Observation:

  • A rare case of small cell carcinoma originating in the epididymis is presented.
  • The patient experienced retroperitoneal recurrence, indicating an aggressive disease course.

Findings:

  • Multimodal therapy, including chemotherapy and retroperitoneal lymph node dissection, was required for disease management.
  • The aggressive nature and poorly characterized treatment of this specific EPSCC subtype were noted.

Implications:

  • This case contributes to understanding the behavior of rare extrapulmonary small cell carcinomas.
  • It underscores the need for aggressive management in cases of recurrence.

More Related Videos

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...