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Chronic inflammatory arthritis after treatment with high-dose interleukin-2 for malignancy
E M Massarotti1, N Y Liu, J Mier
1Department of Medicine, New England Medical Center, Boston, Massachusetts 02111.
The American Journal of Medicine
|June 1, 1992
Abstract:
Interleukin-2 (IL-2) immunotherapy resulted in the development of inflammatory arthritis in three male patients with metastatic cancer. Two patients developed a clinical picture consistent with rheumatoid arthritis. A third patient with a remote history of Reiter's syndrome developed a recrudescence of an inflammatory arthritis after treatment with IL-2. The clinical, laboratory, and histologic data on the patients and the potential pathophysiologic mechanisms are discussed.