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Penetrance estimate of the fra(X) gene using Pointer versus direct estimate
A F de Haan1, A P Smits, D F Smeets
1Department of Medical Statistics, University Hospital, Nijmegen, The Netherlands.
American Journal of Medical Genetics
|April 1, 1992
Abstract:
Direct estimate of the penetrance of the fra(X) gene was compared with the estimate using the Pointer computer program. Direct estimate gave overall penetrances of 85% for male and 64% for female carriers. The estimates calculated by the Pointer program were 82% for males and 38% for females. It is argued that the use of the Pointer program gives incorrect estimates of the penetrance of the fra(X) gene.