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Retinoid receptor subtypes in sebaceous cell carcinoma of the eyelid
Nitin Chakravarti1, Hossein G Saadati, Adel K El-Naggar
1Department of Head & Neck/Thoracic Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston TX 77030, USA.
Purpose:
To study retinoid receptor expression in sebaceous cell carcinoma of the eyelid.
Methods:
Expression of retinoid receptors (RAR alpha, beta, and gamma and RXR alpha, beta, and gamma) in tumor specimens from 10 patients with sebaceous cell carcinoma of the eyelid and in 3 normal incidental tarsus specimens from healthy adults without cancer was studied immunohistochemically by using antiretinoid receptor antibodies.
Results:
In all 3 specimens of normal tarsus, all 6 retinoid receptors were expressed. RARalpha expression was absent in 3 tumors and was decreased in 3 tumors compared with expression in the control tissues. RARbeta expression in carcinomas was primarily perinuclear; 6 tumors showed increased RARbeta expression compared with controls. RARgamma expression was absent in 4 tumors and was decreased in 2 tumors compared with controls. RXRalpha nuclear expression was decreased compared with controls in 5 tumors. RXRbeta expression was low in 7 tumors. RXRgamma expression was absent in 6 tumors.
Conclusions:
Aberrant expression of retinoid receptors in sebaceous cell carcinoma of the eyelid might play a role in the pathogenesis and progression of this carcinoma.
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