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Updated: Aug 15, 2026
Dissection of Human Vitreous Body Elements for Proteomic Analysis
Published on: January 23, 2011
Vitreous leptin levels in retinal disease
D Maberley1, J Z Cui, J A Matsubara
1Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada. crtg_vancouver@hotmail.com
Background/Aims:
The purpose of this study was to investigate the relationship between vitreous leptin levels and retinal diseases.
Methods:
Levels of vitreous leptin were evaluated in proliferative diabetic retinopathy (PDR) and a variety of other retinopathies including: macular disease, neovascular maculopathies, primary retinal detachments, and vascular occlusive disease.
Results:
In patients with PDR (N=7), the average vitreous level of leptin (37.4 ng/ml) was significantly higher than that in patients with PVR (<1.0 ng/ml, P<0.05). Vitreous leptin level in patients with PVR or macular disease (N=18), with or without diabetes, was not significantly different from the control subjects who had retinal detachment only (N=7).
Conclusion:
The results show that the leptin level in vitreous taps is elevated in PDR. We suggest that leptin plays an active role in PDR.
