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Homocysteine and cognitive function in institutionalised elderly A cross-sectional analysis.

M Manders1, E Vasse, L C P G M de Groot

  • 1Division of Human Nutrition, Wageningen University, 8129, 6700, EV Wageningen, The Netherlands. marleen.manders@wur.nl

European Journal of Nutrition
|July 30, 2005
PubMed
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This study found no significant link between homocysteine levels and cognitive function in very old institutionalized individuals. Further research is needed to understand homocysteine

Area of Science:

  • Gerontology
  • Neuroscience
  • Biochemistry

Background:

  • Previous studies suggest a link between homocysteine and cognitive decline or dementia in various populations.
  • Research has explored this association in both patient groups and healthy elderly individuals.

Purpose of the Study:

  • To investigate the hypothesis that homocysteine levels are inversely associated with cognitive function.
  • Focus on a specific population: institutionalized elderly individuals aged 60 years and above (n=157).

Main Methods:

  • Utilized baseline data from an intervention study involving institutionalized elderly (median age 83).
  • Cognitive function assessed using the Alzheimer's disease Assessment Scale-cognitive subscale (ADAS-cog).
  • Analyzed the association between fasting plasma homocysteine and ADAS-cog scores via multiple linear regression.

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Main Results:

  • Homocysteine levels did not show a significant relationship with ADAS-cog scores in the crude model (beta = 0.061; p = 0.45).
  • Age was significantly associated with ADAS-cog scores (beta = 0.161; p < 0.05).
  • Adjusting for age did not establish a significant association between homocysteine and cognitive function.

Conclusions:

  • No association was found between homocysteine levels and cognitive function in this cohort of very old institutionalized subjects.
  • Findings suggest homocysteine may not be a significant predictor of cognitive function in this specific demographic.