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Homocysteine and cognitive function in institutionalised elderly A cross-sectional analysis
M Manders1, E Vasse, L C P G M de Groot
1Division of Human Nutrition, Wageningen University, 8129, 6700, EV Wageningen, The Netherlands. marleen.manders@wur.nl
Background:
Several cross-sectional, case-control and prospective studies revealed a relation between homocysteine and cognitive function or dementia. These studies included either patient populations or healthy, community- dwelling elderly people.
Aim Of The Study:
In this study we tested the hypothesis that homocysteine was inversely associated with cognitive function in a population of institutionalised elderly (aged >/= 60 y; n = 157).
Methods:
For testing this hypothesis baseline data of a recently conducted intervention study in institutionalised elderly (median age 83 years) were used. Cognitive function was evaluated by the cognitive subscale of the Alzheimer's disease Assessment Scale (ADAS-cog). The association between fasting plasma homocysteine level and cognitive function was investigated by multiple linear regression analysis.
Results:
In the crude model homocysteine concentration was not significantly related to ADAS-cog score (beta = 0.061; p = 0.45). Age was found to be related to ADAS-cog score (beta = 0.161; p < 0.05). Adjusting for age did however not result in a relation between homocysteine and cognitive function.
Conclusions:
In our study no association was found between homocysteine and cognitive function in a population of very old institutionalised subjects.
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