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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients

A Amirkhani1, C Rajda, B Arvidsson

  • 1Department of Analytical Chemistry, Institute of Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden.

European Journal of Neurology
|August 2, 2005
PubMed
Summary

Tryptophan metabolism, specifically the kynurenine/tryptophan ratio, is altered in multiple sclerosis (MS) patients treated with interferon-beta. This suggests the enzyme indolamine-2,3-dioxygenase plays a role in MS pathogenesis.

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