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Updated: Aug 16, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
[Emergent strategies in interventional cardiology]
Jiro Aoki1, Gastón A Rodríguez-Granillo, Patrick W Serruys
1Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
Sudden cardiac death remains a significant risk in coronary artery disease despite advances. New percutaneous treatments and diagnostic tools offer hope for better plaque detection and myocardial ischemia management.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
Background:
- Sudden cardiac death remains prevalent in coronary artery disease (CAD) patients.
- Ischemic heart disease often requires combined therapies with persistent symptoms.
Purpose of the Study:
- To review recent advances in percutaneous interventions and diagnostic tools for CAD.
- To highlight ongoing research for improved diagnosis and treatment of vulnerable plaque and myocardial ischemia.
Main Methods:
- Review of current and emerging percutaneous interventional treatments.
- Discussion of novel diagnostic tools for vulnerable plaque assessment.
- Exploration of research in therapeutic angiogenesis and myogenesis.
Main Results:
- Development of percutaneous treatments for vulnerable plaque and myocardial ischemia.
- Advancements in catheter-based devices for plaque detection (lipid-rich core, thin fibrous cap, remodeling).
- Emerging research in drug-eluting stents and catheter-based bypass grafts.
Conclusions:
- Percutaneous approaches are expanding diagnostic and therapeutic options for CAD.
- Ongoing research promises further advancements in managing ischemic heart disease and reducing sudden cardiac death.
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